sPLS Liver Toxicity Case Study

For background information on the (s)PLS method, refer to the PLS Methods Page.

This case study will use a PLS2 framework. To read an example of a PLS1 methodology, click here.

The R script used for all the analysis in this case study is available here.

More information on Plots

For a more in depth explanation of how to use and interpret the plots seen, refer to the following pages:

• plotIndiv() – Sample Plot
• plotVar() – Correlation Circle Plot
• network() – Relevance Network Graph
• cim() – Cluster Image Maps

References

1. Tenenhaus M. (1998) La régression PLS: théorie et pratique. Paris: Editions Technic.
2. Wold, S., Sjöström, M., and Eriksson, L. (2001). Pls-regression: a basic tool of chemometrics. Chemometrics and intelligent laboratory systems, 58(2), 109–130.
3. Bushel, P., Heinloth, A., Li, J., Huang, L., Chou, J., & Boorman, G. et al. (2007). Blood gene expression signatures predict exposure levels. Proceedings Of The National Academy Of Sciences, 104(46), 18211-18216. https://doi.org/10.1073/pnas.0706987104