Multilevel Liver Toxicity Case Study

There is significant overlap between the method used here and that used in the other sPLS Case Study on this same dataset. Hence, things like the preliminary exploration and model tuning will be omitted here. The tuning output used in this case study can be downloaded here.

For background information on the (s)PLS method, refer to the PLS Methods Page.

The R script used for all the analysis in this case study is available here.

More information on Plots

For a more in depth explanation of how to use and interpret the plots seen, refer to the following pages:

• plotIndiv() – Sample Plot
• cim() – Cluster Image Maps

References

1. Bushel, P., Heinloth, A., Li, J., Huang, L., Chou, J., & Boorman, G. et al. (2007). Blood gene expression signatures predict exposure levels. Proceedings Of The National Academy Of Sciences, 104(46), 18211-18216. https://doi.org/10.1073/pnas.0706987104